{"id":1249,"date":"2019-12-09T15:53:58","date_gmt":"2019-12-09T15:53:58","guid":{"rendered":"http:\/\/192.168.0.72\/?p=1249"},"modified":"2019-12-16T21:50:16","modified_gmt":"2019-12-16T21:50:16","slug":"las-nanoparticulas-ultrapequenas-matan-las-celulas-cancerosas-de-manera-inusual","status":"publish","type":"post","link":"https:\/\/site.hsr.gob.pe\/?p=1249","title":{"rendered":"Las nanopart\u00edculas ultrapeque\u00f1as matan las c\u00e9lulas cancerosas de manera inusual"},"content":{"rendered":"
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Los cient\u00edficos se sorprendieron al encontrar que unas nanopart\u00edculas ultra peque\u00f1as y fluorescentes – originalmente desarrolladas para iluminar los tumores para la cirug\u00eda – tambi\u00e9n pueden matar a las c\u00e9lulas cancerosas mediante la activaci\u00f3n de un tipo de muerte celular que no se observa f\u00e1cilmente.<\/span><\/div>\n
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\nEl descubrimiento – y c\u00f3mo probar las nanopart\u00edculas en cultivos celulares y ratones – est\u00e1 publicado en la revista\u00a0 <\/span><\/span><\/span><\/span>Nature Nanotechnology<\/span><\/span><\/span><\/span><\/i><\/span><\/p>\n


\nUno de los principales investigadores, Ulrich Wiesner, profesor de ingenier\u00eda en la Universidad de Cornell en Ithaca, Nueva York, dice: <\/span><\/span><\/span><\/span><\/span><\/p>\n


\nSi se trata de una nanopart\u00edcula para matar el c\u00e1ncer, ser\u00eda exactamente la manera en que se har\u00eda<\/span><\/span><\/span><\/span><\/span><\/p>\n

Las nanopart\u00edculas son part\u00edculas diminutas de una dimensi\u00f3n no mayor de 100 nan\u00f3metros. <\/span><\/span><\/span>Tienen propiedades inusuales en comparaci\u00f3n con el mismo material a una escala m\u00e1s grande, y los cient\u00edficos e ingenieros est\u00e1n aplicando en muchos campos, incluyendo la electr\u00f3nica y la biomedicina.<\/span><\/span><\/span><\/span><\/span><\/p>\n

Las nanopart\u00edculas del nuevo estudio – llamadas puntos de Cornell, o puntos C – son part\u00edculas de s\u00edlice fluorescentes ultra peque\u00f1as, con un di\u00e1metro de 5 nan\u00f3metros.<\/span><\/span><\/span><\/span><\/span><\/p>\n

Fueron desarrolladas originalmente por el profesor Wiesner hace m\u00e1s de 10 a\u00f1os como una herramienta para la cirug\u00eda del c\u00e1ncer. <\/span><\/span><\/span><\/span><\/span>Se adhieren a las c\u00e9lulas cancerosas y las iluminan, a los cirujanos ver d\u00f3nde tienen que cortar.<\/span><\/span><\/span><\/span><\/span><\/p>\n

Las part\u00edculas tambi\u00e9n fueron utilizadas a ser utilizadas para la administraci\u00f3n dirigida de f\u00e1rmacos.<\/span><\/span><\/span><\/span><\/span><\/p>\n

Propiedades terap\u00e9uticas intr\u00ednsecas<\/span><\/span><\/span><\/span><\/span><\/b><\/p>\n

El nuevo estudio muestra que los puntos de Cornell dirigidos al c\u00e1ncer pueden matar a las c\u00e9lulas cancerosas sin tener que llevar medicamentos. <\/span><\/span><\/span>
\nLa autora directora, Michelle Bradbury, directora de imagen intraoperatoria en el\u00a0 <\/span><\/span>Memorial Sloan Kettering Cancer Center<\/span><\/span><\/i> \u00a0de Nueva York, Nueva York, se\u00f1ala:<\/span><\/span><\/span><\/p>\n

\u00abDe hecho, esta es la primera vez que hemos detectado que la part\u00edcula tiene propiedades terap\u00e9uticas intr\u00ednsecas\u00bb.<\/span><\/span><\/span><\/p>\n

\u00abLa part\u00edcula es bien tolerada en un tejido saludable\u00bb, explica el Prof. Wiesner, \u00bb <\/span><\/span>estilo =\u00bb vertical-pero en cuanto se tiene un tumor, y bajo condiciones muy espec\u00edficas, estas part\u00edculas se requieren en asesinas<\/span><\/span><\/i> \u00ab.<\/span><\/span><\/span><\/p>\n

Los investigadores descubrieron las propiedades de los puntos de Cornell para combatir el c\u00e1ncer cuando estaban tratando de descubrir c\u00f3mo podr\u00edan sufrir ser toleradas grandes. <\/span>Se enfrentaron a varios experimentos durante varios a\u00f1os.<\/span><\/span><\/span><\/p>\n

Entonces, para su sorpresa, descubrieron que cuando las altas dosis de puntos de Cornell recubiertos de p\u00e9ptidos fueron incubadas con c\u00e9lulas de c\u00e1ncer – y en particular cuando las c\u00e9lulas fueron privadas de nutrientes – las part\u00edculas tomaron hierro del medio ambiente y lo suministraron a las c\u00e9lulas cancerosas<\/span><\/span><\/span><\/p>\n

La entrega de hierro a las c\u00e9lulas desencadena un tipo de muerte celular llamada ferroptosis, que rompe la membrana celular, que es diferente a la muerte celular por fragmentaci\u00f3n m\u00e1s observada conocida como apoptosis.<\/span><\/span><\/span><\/p>\n

\u00abOla de destrucci\u00f3n\u00bb<\/span><\/span><\/span><\/b>
\n El Prof. Wiesner dice que solo 24-48 horas despu\u00e9s de la exposici\u00f3n a los puntos de Cornell, observa c\u00f3mo se puede \u00abextender la ola de destrucci\u00f3n\u00bb por todo el cultivo de c\u00e9lulas de c\u00e1ncer.<\/span><\/span><\/p>\n

En otros experimentos se inyectan dosis altas de los puntos de Cornell recubiertos en ratones inyectados con tumores de melanoma y se detectan que se redujeron los tumores sin causar reacciones adversas.<\/span><\/span><\/p>\n

Los autores concluyen sus hallazgos encontrados que la ferroptosis puede ser dirigida con nanopart\u00edculas de s\u00edlice ultra peque\u00f1as y puede tener un potencial terap\u00e9utico \u201d.<\/span><\/span><\/p>\n

\u201c <\/span><\/span>Hemos encontrado otra herramienta en la que la gente no hab\u00eda pensado en absoluto hasta ahora. <\/span><\/span>, dijo el Prof. Ulrich Wiesner.<\/span><\/span><\/span><\/i><\/p>\n

Los investigadores ahora planean probar c\u00f3mo funcionan los puntos de Cornell con otras terapias est\u00e1ndar en diferentes tipos de tumores. <\/span><\/span><\/span>Quieren que sean m\u00e1s frecuentes antes de comenzar las pruebas en seres humanos.<\/span><\/span><\/span><\/span><\/p>\n

El equipo tambi\u00e9n estar\u00e1 explorando formas de adaptar las part\u00edculas para dirigirse a tipos espec\u00edficos de c\u00e1ncer. <\/span><\/span><\/span><\/span>
\n..HSR<\/span><\/span><\/span><\/span><\/b><\/i><\/p>\n<\/div>\n<\/div>

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